Monday, 22 January, 2018

Breast cancer survival 'unaffected' by presence of faulty gene

Miss Jolie 42 famously chose to have her breasts ovaries and fallopian tubes removed to reduce her cancer risk after her mother died of ovarian cancer aged just 56 Many women uninformed about breast cancer surgery options
Freda Brock | 13 January, 2018, 05:58

A report of the research, published in The Lancet Oncology, concluded: 'The study showed no significant difference in overall survival or distant disease-free survival between patients carrying a BRCA1 or BRCA2 mutation and patients without these mutations after a diagnosis of breast cancer'. According to the paper, this is the largest study of its kind to look at breast cancer outcomes based on a woman's BRCA mutation status.

Two notorious genetic mutations linked with breast cancer may not impact how long a woman will survive, a new study has found. About 12 percent of the patients had a BRCA mutation, yet again confirming the association between this "faulty gene" and breast cancer.

The researchers say that in the future this information could help women and their doctors make informed choices about treatment.

The BRCA1 and BRCA2 genes play a critical role maintaining the genetic stability of cells, and produce proteins responsible for repairing damaged DNA.

The agency initially approved AstraZeneca Pharmaceutical's Lynparza (olaparib tablets) in 2014 to treat advanced ovarian cancer caused by mutations in BRCA1 or BRCA2.

These results don't mean the BRCA mutations aren't important; they still increase the risk of getting breast and ovarian cancers in the first place, for example.

"Our data provides some reassurance that patients who are diagnosed with a BRCA gene fault as part of their cancer treatment journey can complete and recover from their breast cancer treatment, which is important", she said.

Zidane gets Real backing from Hierro
The Welshman's first start since his return from the calf injury he suffered past year was, at least personally, a successful one. Despite losing 2-1 at Villarreal , who are now sixth in La Liga, Leganes progressed on away goals having won the first leg 1-0.

Some women have previously chose to take preventative measures, such as pre-emptive mastectomies, when they discover they have faulty genes.

Angelina Jolie made headlines when she underwent preventative surgery after learning she had an up to 87% chance of developing breast cancer. Half had breast-conserving surgery, half had a mastectomy, and fewer than 1% had no breast surgery.

"The FDA also expanded the approval of Myriad's BRCAnalysis CDx, a companion diagnostic to olaparib, to include the detection of BRCA mutations."/ BRCA Gene Mutation" / BRCA-mutated HER2-negative metastatic breast cancer.

'However, our findings suggest that this surgery does not have to be immediately undertaken along with the other treatment.

Fiona MacNeill, of the Royal Marsden NHS Foundation Trust, who was not involved in the research, said: "This study can reassure young women with breast cancer, particularly those with triple negative cancer or who are BRCA carriers, that breast conservation with radiotherapy is a safe option in the first decade after diagnosis and double mastectomy is not essential or mandatory at initial treatment".

"Decisions about timing of additional surgery aimed at reducing future second primary-cancer risks should take into account patient prognosis associated with the first malignancy and patient preferences", the authors write.

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