Friday, 17 August, 2018

New drug approved for treatment of breast cancer

Lynparza Lynparza
Ben Pena | 16 January, 2018, 19:22

Lynparza, or olaparib, has been approved by the U.S. Food and Drug Administration to treat spreading breast cancer caused by a BRCA gene mutation.

He told us: "Recently it has become clear that there is headroom for further cancer treatments harnessing Lynparza, other than ovarian cancer".

The agency also approved a companion blood test from Myriad Genetic Laboratories Inc. for detecting BRCA mutations and determining which patients likely would benefit from Lynparza.

These include Zejula in phase 2 trials in combination with Merck & Co.'s Keytruda for use in ovarian or breast cancer, Lynparza in combination with AZ's own immunotherapy Imfinzi in solid tumours, while Clovis' Rubraca is being studied in combination with BMS' Opdivo in prostate cancer. For the record, Lynparza belongs to a drug class called PARP inhibitors, that usually block the enzyme involved in repairing damaged DNA, generating a potential slowdown or termination in tumor growth.

The FDA's approval is based on data showing that Lynparza - developed by AstraZeneca working together with Merck (known as MSD outside the US and Canada) - prolonged the time patients lived without their cancer progressing, compared to standard-of-care chemotherapy. It is the first time any drug has been approved to treat certain patients with metastatic breast cancer who have a BRCA gene mutation.

Barca mount impressive comeback to beat Real Sociedad
Sevilla slipped to a fourth defeat in their past five La Liga games as Manu Garcia's second-half victor earned Alaves a 1-0 win. Barcelona hope to improve their record at Anoeta as they haven't achieved a victory over the hosts for 10 years.

Lynparza is produced by the British drugmaker AstraZeneca, whose US headquarters are in Wilmington, Del. People who took the drug had an average 7 months of progression-free survival, compared to 4.2 months among people who were given only chemotherapy.

While there is now no cure for metastatic breast cancer, todays approval offers a new, targeted option that may help to delay disease progression for these patients, Dr. Susan M. Domchek at the University of Pennsylvanias Abramson Cancer Center said in a statement. The data from the OlympiAD trial can be found in the June 2017 issue of the New England Journal of Medicine. However, such a complete remission was seen in only 1.5 percent of patients treated with chemotherapy.

"While there is now no cure for metastatic breast cancer, today's approval offers a new, targeted option that may help to delay disease progression for these patients", added Domchek, who is a national leader on the OlympiAD trials.

All patients were previously treated with chemotherapy.

Olaparib was first developed as a cancer treatment following landmark research by United Kingdom scientists at the Breast Cancer Now Research Centre at The Institute of Cancer Research, London in 2005, who showed for the first time that cancer cells with BRCA1 and BRCA2 mutations were very sensitive to PARP inhibitors.

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