He told us: "Recently it has become clear that there is headroom for further cancer treatments harnessing Lynparza, other than ovarian cancer".
The agency also approved a companion blood test from Myriad Genetic Laboratories Inc. for detecting BRCA mutations and determining which patients likely would benefit from Lynparza.
These include Zejula in phase 2 trials in combination with Merck & Co.'s Keytruda for use in ovarian or breast cancer, Lynparza in combination with AZ's own immunotherapy Imfinzi in solid tumours, while Clovis' Rubraca is being studied in combination with BMS' Opdivo in prostate cancer. For the record, Lynparza belongs to a drug class called PARP inhibitors, that usually block the enzyme involved in repairing damaged DNA, generating a potential slowdown or termination in tumor growth.
The FDA's approval is based on data showing that Lynparza - developed by AstraZeneca working together with Merck (known as MSD outside the US and Canada) - prolonged the time patients lived without their cancer progressing, compared to standard-of-care chemotherapy. It is the first time any drug has been approved to treat certain patients with metastatic breast cancer who have a BRCAgene mutation.
Barca mount impressive comeback to beat Real Sociedad Sevilla slipped to a fourth defeat in their past five La Liga games as Manu Garcia's second-half victor earned Alaves a 1-0 win. Barcelona hope to improve their record at Anoeta as they haven't achieved a victory over the hosts for 10 years.
Lynparza is produced by the British drugmaker AstraZeneca, whose US headquarters are in Wilmington, Del. People who took the drug had an average 7 months of progression-free survival, compared to 4.2 months among people who were given only chemotherapy.
While there is now no cure for metastatic breast cancer, todays approval offers a new, targeted option that may help to delay disease progression for these patients, Dr. Susan M. Domchek at the University of Pennsylvanias Abramson Cancer Center said in a statement. The data from the OlympiAD trial can be found in the June 2017 issue of the New England Journal of Medicine. However, such a complete remission was seen in only 1.5 percent of patients treated with chemotherapy.
"While there is now no cure for metastatic breast cancer, today's approval offers a new, targeted option that may help to delay disease progression for these patients", added Domchek, who is a national leader on the OlympiAD trials.
All patients were previously treated with chemotherapy.
Olaparib was first developed as a cancer treatment following landmark research by United Kingdom scientists at the Breast Cancer Now Research Centre at The Institute of Cancer Research, London in 2005, who showed for the first time that cancer cells with BRCA1 and BRCA2 mutations were very sensitive to PARP inhibitors.
It feels like one of the worst winters ever, and the terrible weather conditions are set to deteriorate once again tonight. The upgraded alert also applies to Donegal, Leitrim, Mayo, Sligo, Clare, Cork and Kerry.
Meanwhile, the company has been steadily growing its range of products and had recently forayed into the packaged water segment. Reports suggested that in 2016-17, Patanjali had crossed a turnover of Rs 10,500 crore.
Now that they Trump Administration is cracking down on illegal immigrants , he was ordered to be deported back to Mexico. The ICE officials finally said that because there was no DACA law now in place, Jorge Garcia had to leave the country.
E3 officially begins Tuesday, June 12, though the major press conferences typically happen ahead of the show itself. Now we're hearing reports that we'll be hearing and seeing more of much more of the game at E3 this year.
While the defense chipped in a touchdown on a 48-yard fumble return by linebacker Telvin Smith , Bortles kept the Jaguars moving. The Patriots had to settle for a 31-yard gain, but it set up White's first touchdown as the Patriots answered Tennessee's score.
A showdown between the son of Creed vs. the son of Drago will be one of the most anticipated fictional boxing matches on screen. The challenge now for the production will be to make sure that the narrative doesn't too closely mimic Rocky IV .
Simon Atai tried to hang around, but Mavi continued his work at the other end, getting Heagi Toua clean bowled for an 8-ball duck. The rest was taken care of by 19-year-old Jharkhand left-arm spinner Roy, who ran through the middle order.
A 23-year-old Vancouver resident involved directly in the shooting died of his injuries in hospital, Vancouver Police said. The 15-year-old boy from Coquitlam was hit by a stray bullet as two men exchanged gunfire on Saturday night.
Anthony Joshua HITS OUT at Joseph Parker camp over fake news
That's as far as I know. "I am looking forward to it, training camp is underway and before you know it March 31 will be upon us". Tickets for the clash will start at £40, rising in categories up to £600 - with the full VIP treatment costing thousands.
BP shares slide on $1.7bn charge for Deepwater Horizon
BP also expects to be hit by an additional $3bn of Gulf-related costs this year, up from a previous estimate of $2bn. It covers remaining claims for losses in connection with the incident, as well as other claims settled by court.
North Korea scoffs at Trump's 'nuclear button' tweet
Bush, has said North Korean leader Kim Jong Un has turned out to be a smarter operator on the worldwide stage than she expected. The headline of the story that ran on January 11 was " Donald Trump Signals Openness To North Korea Diplomacy In Interview".
Alia Bhatt and Ranveer Singh shoot for Gully Boy in slums
The entire team is super-excited for commencing the shoot and shared their joy with their fans through a social media post. While Alia wore a hijab and traditional suit symbolising to be Muslim, Ranveer posed in jeans and shirt with short hair.
Colombia's ELN rebels must halt attacks, restart talks
Mr Guterres met with officials of the Government and Armed Forces, as well as with FARC-EP leadership and the Catholic Church. The ELN that was formed in 1964 is Colombia's remaining guerrilla group with less than 2,000 combatants.
FBI 'warned' Kushner on Murdoch's ex-wife
The Chinese embassy in Washington said the information in the Journal's article was "full of groundless speculations". One source tells the WSJ that this isn't the only time Deng Murdoch has popped up on counterintelligence radar.
DACA recipients can now request renewal status, per reports
Government funding expires midnight Friday without a deal in place, and some government functions will begin to go dark. Mr Trump's staunchest supporters consider any route to citizenship for the Dreamers to be an amnesty for lawbreakers.
Nissan debuts new Xmotion SUV concept
On the inside, the Xmotion gets a little more concept-like, and Nissan says it's created to echo a traditional Japanese landscape. The interior console was built based on a method of traditional Japanese nailless wood joining known as kanawa tsugi .