Saturday, 18 August, 2018

Oral antibiotics may up risk of kidney stones

Antibiotics May Raise the Risk for Kidney Stones Antibiotics may play role in more adolescents getting kidney stones
Ben Pena | 14 May, 2018, 09:25

The risks for children under 18 were significantly higher than for adults.

Inning accordance with the United States National Institute of Diabetes and Gastrointestinal and Kidney Illness, kidney stones emerge following mineral accumulation in a client's urine.

They found that five classes of oral antibiotics - oral sulfas, cephalosporins, fluoroquinolones, nitrofurantoin, and broad-spectrum penicillins - were associated with a diagnosis of kidney stone disease.

Kidney stones are not only painful, they also increase the risk for fragile bones, hypertension and heart disease.

The findings were released online May 10 in the Journal of the American Society of Nephrology.

It is still unknown why kidney stones are on a hike these days but according to the study, consuming antibiotics certainly play a major role when it comes to prescribing them to children more than that of adults.

The lead author, Dr. Gregory E. Tasian, a urologist at the Children's Hospital of Philadelphia, said the mechanism is unclear, but that the most likely explanation is a complex interaction of the drugs with the urinary or gut microbiome.

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Oral antibiotics could be responsible for the dramatic increase of kidney stones, according to a new study that covered 13 million people.

The strongest risks for kidney stones were in children and adolescents.

For the study, the team analysed prior antibiotic exposure for almost 26,000 patients with kidney stones, compared to almost 260,000 control subjects. Risk did seem to decrease as time passed after taking these antibiotics, the researchers write, but it remained elevated for up to five years. Previous research has shown that children receive more antibiotics than any other age group, and 30 percent of antibiotics prescribed during ambulatory care visits are inappropriate. But prior research has cited a possible association with disturbances in the bacterial makeup (microbiome) of the intestinal and urinary tracts, which is often sparked by antibiotics. He added, "Our findings suggest that antibiotic prescription practices represent a modifiable risk factor - a change in prescribing patterns might decrease the current epidemic of kidney stones in children".

This prolonged amount of time was picked since kidney stones can take weeks and even months to form. Their goal is to expand this research into broader, population-based studies to better understand how variations in microbiome composition may influence the development of kidney stones.

Tasian is an assistant teacher of urology and public health with the University of Pennsylvania Perelman School of Medication.

" This research study is another pointer that doctors need to bear in mind prospective negative impacts of prescription antibiotics and have to promote proper antibiotic stewardship".

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