Tuesday, 16 October, 2018

Incredible breakthrough as doctors ‘cure’ woman with advanced breast cancer

For some breast cancer patients, the chemo decision may now be easier Breast cancer treatment: More women may avoid chemotherapy thanks to breakthrough research
Ben Pena | 06 June, 2018, 05:42

And we have known that also. "We can de-escalate toxic treatments and do that with certainty".

"Breast cancer treatments have advanced so much that treatments can nearly be tailored for patients and this is extremely welcome news as chemotherapy is a particularly invasive treatment".

"I don't know any doctor who isn't excited about this", he said. It found that for patients in the middle, with scores between 11 and 25, there is a similar rate of cancer-free survival for those who had chemo combined with hormone therapy, and those who had hormone therapy alone, after nine years.

"Chemotherapy is no Shangri-La", Brawley said. No less daunting than the diagnosis itself was the prospect of chemotherapy and its associated side-effects - hair loss, nausea, etc. The test examines genes from a patient's breast cancer biopsy sample and allows doctors to assign a patient a "recurrence score" from 0 to 100, according to a news release from Loyola Medicine announcing the findings.

Findings of the past have indicated that women who met these criteria and scored below ten on the index test could safely skip chemotherapy without raising their rate of recurrence, however, those above 25 would nearly always be advised to use chemotherapy as a necessary treatment to lower risk of recurrence. "I want to live - period.' I can't say how I would have responded to this study, but when it's your life, you'd rather deal with the awful effects of chemo for a relatively short amount of time than die".

And while the new immunotherapy drugs help the body's immune system recognize tumors, they only work in a small percentage of patients.

Another study presented at Sunday's conference found that Merck's immunotherapy drug Keytruda worked better than chemo as initial treatment for most people with the most common type of lung cancer, and with far fewer side effects, noted USA Today.

While the USA doctors who developed the therapy can not be sure how much the infused immune cells contributed to her recovery, the use of pembrolizumab alone has not been very effective for advanced breast cancer in the past.

Mexico strikes back, levying tariffs on USA pork, steel, whiskey
The resulting outcry and threat of retaliatory tariffs by Canada, Mexico, and the European Union gave Beijing cover to do nothing. By Andrew MayedaPresident Donald Trump's zeal for tariffs has yet to derail the global economic outlook.

The new study, called TAILORx, is a large, randomized trial involving thousands of patients. She thanks a routine mammogram to saving her life and, thankfully, didn't have to undergo chemo as her cancer was caught early. Researchers used it to estimate the risk that a cancer will come back based on 21 genes linked with breast cancer recurrence. The women in the "unfavourable" range had to receive chemotherapy.

She had surgery at the end of September followed by a new option.

But Melcher points out that the therapy is complex and expensive and more importantly, requires doctors to find enough infiltrating immune cells in a patient's tumour to make the treatment effective.

Figueredo explained the 9 year-long study like this: Researchers took more than 10,000 women with the most common type of breast cancer that's node-negative estrogen sensitive cancer.

Gilead's Kite unit signed a development agreement for the experimental therapy, Rosenberg said. Should we give them chemotherapy?

He estimates 3000 women a year in the United Kingdom would no longer need chemotherapy because of this trial.

Rachel Rawson, from the charity Breast Cancer Care, said: "Every day, women with certain types of breast cancer face the bad dilemma of whether or not to have the treatment, without hard facts about the benefit for them". A different tactic is needed for solid tumors, such as breast cancer. "Now we're actually peeling back and not treating everyone the same way".

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