Tuesday, 11 December, 2018

Cancer researchers from US and Japan awarded Nobel Medicine Prize

The Nobel Prize laureates in medicine or physiology are shown on a screen at the Karolinska Institute in Stockholm Sweden The Nobel Prize laureates in medicine or physiology are shown on a screen at the Karolinska Institute in Stockholm Sweden
Ben Pena | 01 October, 2018, 17:42

Allison spent 17 years convincing others that this approach could work, leading to approval in 2011 of the drug Yervoy, which showed near-miraculous results for a fraction of patients with a lethal form of skin cancer.

Immunologists James Allison of the United States and Tasuko Honjo of Japan won the Nobel Prize in medicine Monday for research in how the body's natural defenses can fight the scourge of cancer.

Immune checkpoint inhibitor therapy targets proteins made by some immune system cells, as well as some cancer cells. "Immune checkpoint therapy" has revolutionised cancer treatment and has fundamentally changed the way we view how cancer can be managed", the Nobel committee stated.

Thanks to Allison's doggedness, anti-CTLA-4 therapy is now an accepted therapy for cancer and it opened the floodgates for a slew of new immunotherapies, Krummel said.

An immunologist with a Ph.D. from the University of Texas, Austin, he focused on a type of immune system cell called the T cell or T lymphocyte, which plays a key role in fighting off bacterial and viral infections as well as cancer. CTLA- 4 functions as a brake on T cells that inhibits the function of the accelerator.

Allison, 70, conducted basic research on how the immune system - in particular, a cell called a T cell - fights infection.

Samsung's Galaxy Note 9 gets two new colors in the US
Samsung is rectifying that with the Note 9, though it should come to the United Kingdom and other countries over time. It's not as reflective as the mirror-like Midnight Black version, but it has a shiny sports auto vibe to it.

Separately, Prof Honjo discovered a new protein on immune cells, finding that that too acts as a brake. By releasing that brake, Honjo's research had found a "strikingly effective" treatment against cancer. That's because our immune systems typically fight off foreign invaders, such as bacteria and viruses, and mostly ignore the cells created within our bodies - which include cancer cells.

The Nobel Prize laureates for Medicine or Physiology 2018 are James P. Allison, U.S. and Tasuku Honjo, Japan presented at the Karolinska Institute in Stockholm, Sweden October 1, 2018.

Other cancer treatments have been awarded Nobel prizes, including hormone treatment for prostate cancer in 1966, chemotherapy in 1988 and bone marrow transplants for leukemia in 1990.

"However, advanced cancer remains immensely hard to treat, and novel therapeutic strategies are desperately needed", the Nobel Assembly said.

The prize is now worth $1,012,297.05 and will be split between the winners.

The Nobel Prize is the world's most prestigious annual award for outstanding work in physics, chemistry, physiology or medicine, literature and promotion of peace. In 2013, Science magazine named cancer immunotherapy its Breakthrough of the Year, citing Allison's work as crucial to immunotherapy's rapid advancement, and The Economist honoured him with its Innovations Award in Bioscience.

Recommended

Cristiano Ronaldo's girlfriend, 23, backs star amid rape claims Cristiano Ronaldo's girlfriend, 23, backs star amid rape claims According to her account, he went on to rape her anally without a lubricant and then assured her he didn't have HIV/AIDS. Rather than go through the trauma of a court case she chose to reach an out of court settlement with Ronaldo .

Rishi Kapoor's mother Krishna Raj Kapoor passes away Rishi Kapoor's mother Krishna Raj Kapoor passes away Rima Jain and family along with brother Randhir and Rajiv were taking care of the preparations for the funeral. Soha paid respects and called Krishna Kapoor "an incredible personality full of life and passion".

One-game tiebreaker numbers and notes One-game tiebreaker numbers and notes Regardless, the Cardinals did lose to the Brewers, which kept Milwaukee 1/2 game behind Chicago and oh boy did St. The victor at Wrigley gets a spot in the division series and home-field advantage throughout the NL playoffs.

Federal Bureau of Investigation reaches out to second Kavanaugh accuser Federal Bureau of Investigation  reaches out to second Kavanaugh accuser Kavanaugh has called her accusations a "joke" and Judge has said he "categorically" denies the allegations. The administration is said to be working closely with Senate Republicans on the matter, and Arizona Sen.

US Senate Judiciary Comm. Refers Whitehouse's Kavanaugh Accuser to FBI for Investigation US Senate Judiciary Comm. Refers Whitehouse's Kavanaugh Accuser to FBI for Investigation Christine Blasey Ford testified to the Senate committee that he had sexually assaulted her when they were teenagers in the 1980s. Trump ordered the FBI to reopen Kavanaugh's background investigation, delaying a final vote on the nomination.

Manchester United dismiss Zinedine Zidane rumours as nonsense sources Manchester United dismiss Zinedine Zidane rumours as nonsense sources The reality is if that scenario unfolds, it would fly in the face of the Glazer family's ownership of Manchester United . Everyone knows Andriy Yarmolenko is is left-footed.

OnePlus 6T launching soon: Quick facts on upcoming Android flagship OnePlus 6T launching soon: Quick facts on upcoming Android flagship For those in the United States and that prefer stock Android , the Pixel 3 XL and OnePlus 6T will be the two best options. The phone is powered by a Qualcomm Snapdragon 835 processor, coupled with 4GB RAM and 64GB/128GB of internal storage.

Europe extends its Ryder Cup lead over the U.S Europe extends its Ryder Cup lead over the U.S As a result, Woods' record this week reads 0-3, while his overall Ryder Cup output is a disappointing 14.5 points from 36 matches. It turned out to be the most lopsided European triumph since an 18.5-9.5 victory at Ireland's K Club in 2006.

High drama as Kavanaugh, Ford hearing underway High drama as Kavanaugh, Ford hearing underway Flake added later, "And so I will say to these witnesses - these human beings - we owe both of you a honest apology". Both told the committee they, not Kavanaugh, "had the encounter with Dr.

Penn State | Dwayne Haskins Jr. doesnt fold under pressure Penn State | Dwayne Haskins Jr. doesnt fold under pressure Hill in which the receiver made a handsome move on a wide bubble screen, benefiting from a block by Terry McLaurin. McSorley, working from Penn State's 7-yard line, found KJ Hamler on a slant and the young receiver did the rest.

Kanye West Announces Change Of Name Other social media users who had been following Chris Rock's Instagram found the comedian laughing at West throughout the speech. The audience could be heard audibly booing West, and at one point Rock laughed and muttered "oh my god".

‘SNL’ has Matt Damon play an angry Brett Kavanaugh ‘SNL’ has Matt Damon play an angry Brett Kavanaugh As Damon said the actress' name, a cut-out of Milano popped-up from behind him, drawing a big laugh from the studio audience. These attractive , creepy calendars about lifting weights with P.J. and Squee and Donkey Dong Doug.

Powerful typhoon pounds Japan islands Powerful typhoon pounds Japan islands The terminal building was closed for the day and the monorail as well as bus service to the airport were also suspended. This powerful typhoon is now equal to a Category 3 major hurricane in the Atlantic or East Pacific Ocean.

Trump says Federal Bureau of Investigation probe into Kavanaugh is a 'blessing in disguise' Trump says Federal Bureau of Investigation  probe into Kavanaugh is a 'blessing in disguise' Ramirez contacted several former classmates to ask if they recalled the incident and said she couldn't be sure it was Kavanaugh. Jeff Flake, R-Ariz., and Lisa Murkowski, R-Alaska, said they wouldn't vote in favor of the judge's confirmation without one.

Fox Reportedly Sets 'Deadpool 2' Re-Release For December 2018 Fox Reportedly Sets 'Deadpool 2' Re-Release For December 2018 But since Gambit is still in production, it makes sense to push that one back in favor of the film that's been, y'know, made. It should be noted, 20th Century Fox previously even announced a release date for June 2017.